Research Papers

Horizontal Centrifugation leads to up to a 4 fold increase in platelet and leukocyte yield when compared to L-PRF and A-PRF fixed-angle protocols by Miron et al. (2019)

Histological evidence that fixed-angle centrifugation leads to cell accumulation along the distal back surface of PRF tubes whereas horizontal centrifugation leads to more even distribution of cells by Fujioka-Kobayashi et al. (2020)

Further evidence that fixed-angle centrifugation leads to uneven cell accumulation along the distal back surface of PRF tubes by Takahashi et al. (2019)

Evaluation of 24 different protocols for the optimization of PRF via horizontal centrifugation by Miron et al. (2020)

Improved growth factor release and cellular bioactivity of PRF produced via horizontal

Evaluation and Quantification of Cell types in Platelet-Rich Fibrin Produced using Fixed-Angle and Horizontal Centrifugation by Castro Pinto

Evidence for Contamination of Silica Microparticles in A-PRF Matrices Prepared Using Silica-Coated Plastic Tubes by Tsujino et al. (2019)

Acute cytotoxic effects of silica microparticles used for coating of plastic PRF tubes on human cells by Masuki et al. (2020)

A technical note on contamination from PRF tubes containing silica and silicone by Miron et al. (2021)

Concentrated-PRF (C-PRF) leads to a 10 fold increase in accumulation of platelets and leukocytes when compared to standard injectable-PRF (i-PRF) by Miron et al. (2019)

Concentrated-PRF (C-PRF) markedly increases growth factor release and cellular activity when compared to standard injectable-PRF (i-PRF) by Fujioka-Kobayashi et al. (2020)

Biological characterization of an albumin gel mixed with liquid C-PRF (Alb-PRF) by Fujioka-Kobayashi et al. (2020)

In vivo study demonstrating the drastic extended resorption properties of Alb-PRF when compared to liquid PRF and standard PRF membranes by Gheno et al. (2020)

Extending the working properties of liquid platelet-rich fibrin using chemically modified PET tubes and the Bio-Cool device by Miron et al. (2022)

Research demonstrating blood draws should be performed within 90 seconds. Effect of patient age and gender on size of PRF-outcomes by Miron et al. (2018)

PRF improves skin fibroblast for facial esthetic procedures by Wang et al. (2019)

PRF improves dental pulp cells and lowers inflammation of the pulp cells cultured with LPS by Chai et al. (2019)

Data demonstrating liquid-PRF is superior to PRP on cellular activity by Miron et al. (2017)

Use of liquid-PRF as a drug-delivery system by Miron et al. (2018)

PRF has anti-inflammatory properties on human macrophages and dendritic cells by Zhang et al. (2019)

Anti-inflammatory response of PRF in macrophages by Nasirzade et al. (2019)

Issues relating to the report of g-forces in Leukocyte and Platelet Rich Fibrin (L-PRF) by Miron et al. (2018)

Standardization of PRF for scientific purposes by Miron et al. (2019)

PRF induces greater knee regeneration when compared to PRP by Abd El Raouf et al. (2017)

Histological Evaluation of Gingival and Intrabony Periodontal Defects Treated with Platelet-Rich Fibrin Using Different Protocols: A Canine Study by Shirakata et al. (2021)

Comparison of the effects of platelet concentrates produced by high and low-speed centrifugation protocols on the healing of critical-size defects in rat calvaria: a microtomographic and histomorphometric study by da Silva et al. (2022)

RCF affects TGF-beta distribution in PRF produces via horizontal centrifugation by Kargarpour et al. (2020)

Liquid-PRF and albumin gel: Bioassays for TGF-beta by Kargarpour et al. (2020)

PRF neutralizes hydrogen peroxide-induced cell death in gingival fibroblasts by Kargarpour et al. (2020)

Liquid PRF Reduces the Inflammatory Response and Osteoclastogenesis in Murine Macrophages by Kargarpour et al. (2021)

Antibacterial effects of platelet-rich fibrin produced by horizontal centrifugation by Feng et al. (2020)

Distribution and quantification of activated platelets in platelet-rich fibrin matrices by Sato et al. (2020)

Platelet-Rich Fibrin Increases BMP2 Expression in Oral Fibroblasts via Activation of TGF-β Signaling by Kargarpour et al. (2021)

Platelet-Rich Fibrin Decreases the Inflammatory Response of Mesenchymal Cells by Kargarpour et al. (2021)

Preparation, characterization and biological properties of a novel bone block composed of platelet-rich fibrin and a deproteinized bovine bone mineral by Feng et al. (2022)

Fibrinogen Concentrations in Liquid PRF Using Various Centrifugation Protocols by Kargarpour et al. (2022

Effect of relative centrifugal force on the biological properties of liquid platelet-rich fibrin produced via horizontal centrifugation by Feng et al. (2022)

Effects of platelet rich fibrin produced by three centrifugation protocols on bone neoformation in defects created in rat calvaria by Ferreira Sávio et al. (2023)

PRF induces stem cell recruitment and activity

Use of PRF produced via horizontal centrifugation on furcation defect regeneration with/without antibiotics. (Lead investigator = Dr. Victoria Lima)

Use of PRF produced via horizontal centrifugation during femur defect regeneration with/without a bone grafting material (Lead investigator = Dr. Yufeng Zhang)

Systematic Review of PRF by Miron et al. (2017)

Systematic Review of PRF treatment on soft tissue wound healing by Miron et al. (2016)

The use of platelet‐rich fibrin to enhance the outcomes of implant therapy: A systematic review by Strauss et al. (2018)

Systematic Review of PRF on gingival recessions in comparison to coronally advanced flap, connective tissue grafting, and enamel matrix derivative by Miron et al. (2020)

Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis by Miron et al. (2021)

Efficacy of platelet-rich fibrin on bone formation, part 1: Alveolar ride preservation by Miron and Fujioka-Kobayashi et al. (2021)

Efficacy of platelet-rich fibrin on bone formation, part 2: Guided bone regeneration, sinus elevation and implant therapy by Fujioka-Kobayashi et al. (2021)

Efficacy of platelet-rich fibrin on socket healing after mandibular third molar extractions by Fujioka-Kobayashi et al. (2021)

Systematic Review of osteonecrosis of the jaw treated with PRF

Miron and Pikos: Use of PRF for guided bone regeneration procedures by Miron et al. (2017)

Miron and Pikos: Use of PRF during sinus Grafting: What is the consensus? by Miron et al. (2018)

Basics of PRF therapy by Miron et al. (2017)

Custom 3-D Bone Allograft Block Fabrication by Mohamed et al. (2020)

Randomized Clinical Trial evaluating PRF with/without a bone grafting material (Lead investigator: Dr. Michel Messora)

Platelet-rich fibrin as a gingival tissue regeneration enhancer by Petrescu et al. (2020)

Histological Evaluation of Gingival and Intrabony Periodontal Defects Treated with Platelet-rich Fibrin Using Different Protocols: A Canine Study by Shirakata et al. (2021)

Periodontal Regeneration using PRF. A first histological case series in humans (Lead investigators: Dr. Anton Sculean and Dr. Raluca Cosgarea)

Use of PRF in combination with dentin grafting for large intrabony defect regeneration (Lead investigator: Dr. Soren Jepsen)

Randomized clinical study evaluating PRF during intrabony defect regeneration.. (Lead investigators: Dr. Anton Sculean and Dr. Raluca Cosgarea)

Randomized clinical study evaluating PRF with/without antibiotics during non-surgical periodontal therapy. (Lead investigator: Dr. Richard Miron)

Use of PRF as a hemostatic agent favoring blood clotting in patients on anti-coagulant therapy by Mourao et al. (2019)

Use of PRF for medication related ONJ by Mourao et al. (2019)

Soft-Tissue Grafting Techniques Associated With Immediate Implant Placement by Bishara et al. (2018)

Soft Tissue Grafting by Bishara  et al. (2018)

3rd molar extraction healing with PRF: A split-mouth randomized study (Lead investigator: Dr. Senthil Selvan)

Temporomandibular joint (TMJ) injections with PRF produced via horizontal centrifugation (Lead investigator: Dr. Benoit Schaller)

Extraction site management with bone grafts with/without PRF. A histological evaluation (Lead investigator: Dr. Luigi Canullo)

Immediate implant placement with PRF and bio-electric stimulation. A pilot study (Lead investigator: Dr. Cameron Lee)

Use of PRF for soft tissue wound healing around implants. A histological evaluation (Lead investigator: Dr. Luigi Canullo)

Use of Platelet Rich Fibrin in Facial Esthetics and The Center for Advanced Rejuvenation and Esthetics

by Miron and Kanter (2021)

Use of Lasers in Facial Esthetics and The Center for Advanced Rejuvenation and Esthetics by Miron and Kanter (2021)

Effect of platelet-rich fibrin (PRF) membranes on the healing of infected skin wounds by Silveira et al. (2022)

Rejuvenating Facial Esthetics with Regenerative and Biocompatible Techniques Part 1: Applications and Opportunities for Cosmetic Dentists by Miron RJ and Davies CE, 2023

Rejuvenating Facial Esthetics with Regenerative and Biocompatible Techniques Part 2: Laser Fundamentals and Platelet-Rich Fibrin Protocols by Miron RJ and Davies CE, 2023

Basics to All-Natural Facial Esthetics. Part 3: Protocols and Clinical Cases by Miron and Davies

Basics to All-Natural Facial Esthetics. Part 2: Scientific Background of Platelet Rich Fibrin and Laser Therapy by Miron and Davies

Use of PRF produced via horizontal centrifugation on hair regeneration. (Lead investigator: Dr. Catherine Davies)

Use of PRF and extended-PRF (Alb-PRF) as a natural biological filler (Bio-Filler). (Lead investigator: Dr. Alireza Pannahpor)

Towards the Development of Novel Biological Facial Fillers by Miron et al.

Osteoinductive ceramics as a synthetic alternative to autologous bone grafting by Yuan et al. (2010)

Maxillary sinus augmentation with microstructured tricalcium phosphate ceramic in sheep by R.J. Klijn et al. (2011)

The homing of bone marrow MSCs to non-osseous sites for ectopic bone formation induced by osteoinductive calcium phosphate by Song et al. (2013)

Micro-structured calcium phosphate ceramic for donor site repair after harvesting chin bone for grafting alveolar clefts in children by A. de Ruiter et al. (2014)

Bone tissue modelling and remodelling following guided bone regeneration in combination with biphasic calcium phosphate materials presenting different microporosity by C. Dahlin et al. (2015)

Defect healing with various bone substitutes by Yip et al. (2015)

Dental materials for cleft palate repair by Sharif et al. (2016)

Osteoinductive potential of 4 commonly employed bone grafts by Miron et al. (2016)

Osteoinductive potential of a novel biphasic calcium phosphate bone graft in comparison with autographs, xenografts, and DFDBA by Miron et al. (2016)

Addition of a synthetically fabricated osteoinductive biphasic calcium phosphate bone graft to BMP2 improves new bone formation by Zhang et al. (2016)

Regeneration of rabbit calvarial defects using biphasic calcium phosphate and a strontium hydroxyapatite-containing collagen membrane by Kitayama et al. (2016)

Histomorphometric Study of New Bone Formation Comparing Defect Healing with Three Bone Grafting Materials: The Effect of Osteoporosis on Graft Consolidation by Zhang et al. (2018)

Evaluation of Bone Stability and Esthetic Result After Immediate Implant Placement Using a Novel Synthetic Bone Substitute in the Anterior Zone: Results After 12 Months by Barroso-Panella et al. (2018)